Pénicaud L, Thompson D A, Le Magnen J
Physiol Behav. 1986;36(3):431-5. doi: 10.1016/0031-9384(86)90310-0.
Comparisons between early daytime and early nighttime effects of 2-deoxy-D-glucose (2DG) injections on food and water intake and rectal temperature were made. Food intake was significantly enhanced by 2DG injections regardless of the phase of the light cycle. In the daytime, water intake was increased by a lower dose of 2DG (200 mg/kg, IP) but there was no further increase at a higher dose (400 mg/kg). At night, the lower dose of 2DG had no effect on water intake but the higher dose suppressed the water intake normally associated with feeding. Administration of 2DG reduced preprandial rectal temperature in a dose dependent fashion in both phases of the light cycle. However, preprandial rectal temperatures were decreased more at night than during the daytime after injection of the higher dose of 2DG. Therefore, 2DG-induced hypothermia is dependent on both the dose of 2DG injected and the phase of the light cycle in which glucoprivation is produced. Furthermore, below a certain level of body temperature, rats markedly reduced drinking behavior while maintaining but not increasing their feeding response to 2DG-induced glucoprivation. These results suggest that behaviors may be directed toward preservations of body temperature in preference to relief of hunger by eating and of thirst by drinking.
对2-脱氧-D-葡萄糖（2DG）注射在白天早期和夜间早期对食物和水摄入量以及直肠温度的影响进行了比较。无论光照周期处于哪个阶段，2DG注射均能显著提高食物摄入量。在白天，较低剂量的2DG（200mg/kg，腹腔注射）可增加水摄入量，但较高剂量（400mg/kg）时则不再进一步增加。在夜间，较低剂量的2DG对水摄入量无影响，但较高剂量会抑制通常与进食相关的水摄入量。在光照周期的两个阶段，2DG的给药均以剂量依赖性方式降低餐前直肠温度。然而，注射较高剂量的2DG后，夜间的餐前直肠温度比白天下降得更多。因此，2DG诱导的体温过低取决于注射的2DG剂量以及产生糖剥夺的光照周期阶段。此外，在体温低于一定水平时，大鼠会显著减少饮水行为，同时维持但不增加它们对2DG诱导的糖剥夺的进食反应。这些结果表明，行为可能优先指向体温的维持，而非通过进食缓解饥饿和通过饮水缓解口渴。
