Shubinskiĭ G Z, Kudaeva O T, Lozovoĭ V P
Biull Eksp Biol Med. 1984 Apr;97(4):468-70.
The proliferative response of human lymphocytes was studied in one-way and two-way mixed lymphocyte cultures (MLC). The maximal proliferation was shown to be attained in a two-way MLC containing unequal quantities of the cells from two paired donors. It was also demonstrated in a one-way MLC that the cells of one of the two paired donors are more effective responders. The most powerful proliferation in the MLC of these donors was observed in the cultures containing the excess of more effective cells. Thymosine increased the response of human lymphocytes in the two-way MLC. In vitro cell preincubation reduced the response in the cultures with a high proliferative response in the control. It has been thus demonstrated that lymphocytes from paired donors possess different functional activity in the MLC.
在单向和双向混合淋巴细胞培养（MLC）中研究了人淋巴细胞的增殖反应。结果显示，在含有来自两个配对供体不等量细胞的双向MLC中可达到最大增殖。在单向MLC中也证实，两个配对供体之一的细胞是更有效的反应细胞。在这些供体的MLC中，在含有过量更有效细胞的培养物中观察到最强的增殖。胸腺素增加了双向MLC中人淋巴细胞的反应。体外细胞预孵育降低了对照中具有高增殖反应的培养物中的反应。因此证明，来自配对供体的淋巴细胞在MLC中具有不同的功能活性。
