Mattingly J A
Cell Immunol. 1984 Jun;86(1):46-52. doi: 10.1016/0008-8749(84)90357-5.
Mice were orally administered sheep erythrocytes (SRBC) in a regimen previously known to produce systemic tolerance to SRBC. Cellular interactions and movement from the gut-associated lymphoid tissue (GALT) to the spleen were found to occur using both in vivo and in vitro transfer systems. The cell in the GALT which initiates the suppression circuit migrates from the GALT to the spleen shortly after contacting antigen. This cell is a T suppressor-inducer (Tsi) cell which interacts with splenic lymphocytes to induce the formation of an effector T suppressor cell (Ts). The Tsi and Ts can be separated from each other by their differential sensitivities to cyclophosphamide. In addition, the Tsi can be separated from other GALT T cells by its inability to bind the lectin, peanut agglutinin. Thus, cell migration and cellular interaction among T cells must occur to result in orally induced tolerance.
给小鼠口服绵羊红细胞（SRBC），采用先前已知的能产生对SRBC全身耐受性的方案。利用体内和体外转移系统发现，细胞相互作用以及从肠道相关淋巴组织（GALT）向脾脏的迁移会发生。在接触抗原后不久，GALT中启动抑制回路的细胞会从GALT迁移到脾脏。这种细胞是T抑制诱导细胞（Tsi），它与脾脏淋巴细胞相互作用以诱导效应T抑制细胞（Ts）的形成。Tsi和Ts可通过它们对环磷酰胺的不同敏感性彼此分离。此外，Tsi因其不能结合凝集素花生凝集素，可与其他GALT T细胞分离。因此，T细胞之间必须发生细胞迁移和细胞相互作用才能导致口服诱导的耐受性。
