Collins J A
Drug Intell Clin Pharm. 1984 May;18(5):402-3. doi: 10.1177/106002808401800509.
A 42-year-old woman with synovial sarcoma developed a skin flare during doxorubicin therapy. With a subsequent dose, erythema, urticaria, and asthma occurred, despite pretreatment with antihistamines. Skin flares occur in about three percent of patients receiving doxorubicin. Rarely, generalized urticaria, angioneurotic edema, or anaphylaxis occur. Local reactions may represent molecular extravasation through vessels, or histamine release from mast cells or basophils. Generalized reactions may involve alternative complement-activation pathways. Pretreatment with antihistamines or corticosteroids sometimes is helpful in preventing recurrences.
一名42岁的滑膜肉瘤女性患者在接受阿霉素治疗期间出现了皮肤潮红。在后续剂量治疗时，尽管预先使用了抗组胺药，仍出现了红斑、荨麻疹和哮喘。接受阿霉素治疗的患者中约有3%会出现皮肤潮红。很少会发生全身性荨麻疹、血管性水肿或过敏反应。局部反应可能代表药物通过血管的分子外渗，或肥大细胞或嗜碱性粒细胞释放组胺。全身性反应可能涉及替代补体激活途径。预先使用抗组胺药或皮质类固醇有时有助于预防复发。
