Souhami L, Feld R
JAMA. 1978 Oct 6;240(15):1624-6.
Urticaria developed above the site of injection with doxorubicin hydrochloride in 11 patients with malignant neoplasms. Generalized urticaria without anaphylaxis developed in one patient, while only local reactions developed in the other ten. A reaction developed in two patients on their first exposure to doxorubicin. Two of the seven patients who received subsequent doxorubicin therapy had further reactions. Urticaria does not seem to be a contraindication to further treatment with doxorubicin if the patient is closely observed. The value of prophylactic antihistamines of corticosteroids is not clear.
11例恶性肿瘤患者在注射盐酸多柔比星的部位上方出现荨麻疹。1例患者出现无过敏反应的全身性荨麻疹，而其他10例仅出现局部反应。2例患者在首次接触多柔比星时出现反应。7例接受后续多柔比星治疗的患者中有2例出现进一步反应。如果对患者进行密切观察，荨麻疹似乎并非多柔比星进一步治疗的禁忌证。预防性使用抗组胺药或皮质类固醇的价值尚不清楚。
