Morton O
Postgrad Med J. 1984;60 Suppl 1:32-5.
A controlled trial was carried out in general practice comparing, in two successive 3 week periods, respiratory function in patients with chronic reversible airway obstruction treated, in the first period with their existing metered dose inhaler (MDI) and in the second period with Duovent , an MDI combining anticholinergic and beta2-stimulant agents respectively. One hundred and twenty-two patients were included. Peak expiratory flow rates were increased to a statistically significant degree during the Duovent period and, during this period, there was a significant reduction in day-time cough, night-time wheeze and night wakings . Global ratings by patients and physicians showed that 76% of patients improved with Duovent , and two-thirds of the patients preferred Duovent to their former MDI. Side effects with Duovent were mild, with dry mouth predominating.
在普通医疗实践中进行了一项对照试验，在连续两个3周期间，对慢性可逆性气道阻塞患者的呼吸功能进行比较。在第一个期间，患者使用现有的定量吸入器（MDI）进行治疗；在第二个期间，使用分别含有抗胆碱能药物和β2激动剂的联合MDI（Duovent）进行治疗。共纳入122名患者。在使用Duovent期间，呼气峰值流速有统计学意义的显著增加，且在此期间，白天咳嗽、夜间喘息和夜间觉醒显著减少。患者和医生的总体评分显示，76%的患者使用Duovent后病情改善，三分之二的患者更喜欢Duovent而不是他们之前使用的MDI。Duovent的副作用较轻，主要是口干。
