A double blind study of imipramine versus zimelidine in treatment of obsessive compulsive neurosis.

Six patients suffering from obsessive compulsive neurosis were randomly allocated into two groups of three patients each and commenced on either imipramine, a noradrenaline re-uptake inhibitor, or zimelidine, a serotonin re-uptake inhibitor. After 4 weeks, the group on zimelidine showed significant reduction of obsessional symptoms as compared to the other group. The response was rapid and sustained over a period of two months.