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[引入相互作用的巨噬细胞和胸腺细胞体外系统的合成聚电解质对辅助活性的影响]

[Effect on helper activity of synthetic polyelectrolytes introduced into an in vitro system of interacting macrophages and thymus cells].

作者信息

Norimov A Sh, Gorbacheva L D, Bogdanova N B, Savinova I V, Khaitov R M

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1984 Mar(3):100-3.

PMID:6233828
Abstract

Our experiments have shown that the joint incubation of thymocytes and syngeneic macrophages in vitro for 60 minutes is accompanied by a certain increase in the helper activity of thymocytes. The presence of polyacrylic acid or the copolymer of acrylic acid and N-vinyl-pyrrolidone, containing 56 mol% of acrylic acid, in this system ensures a considerable increase in the helper activity of thymocytes, incubated jointly with marrow cells and sheep red blood cells and then transferred into a cell culture in vivo.

摘要

我们的实验表明,胸腺细胞与同基因巨噬细胞在体外共同孵育60分钟后,胸腺细胞的辅助活性会有一定程度的增加。在该体系中加入聚丙烯酸或含56摩尔%丙烯酸的丙烯酸与N-乙烯基吡咯烷酮的共聚物,可确保与骨髓细胞和绵羊红细胞共同孵育后再转入体内细胞培养的胸腺细胞的辅助活性大幅增加。

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