Willshaw P, Nielsen S D, Nanas J, Pichel R H, Olsen D B
Artif Organs. 1984 May;8(2):215-9. doi: 10.1111/j.1525-1594.1984.tb04274.x.
The pneumatic artificial heart uses a flexible diaphragm to separate blood from air. The air space behind the diaphragm is connected to the atmosphere during diastole. Blood entering the heart during diastole displaces an equal volume of air into the atmosphere. A pneumotachograph is used to sense this flow of air. Integration of the airflow signal with respect to time yields the volume of air displaced during diastole, which is equal to the volume of blood entering the heart over the same period. This measured filling volume is equal to the cardiac output when averaged over a number of cardiac cycles. Allowance is made for regurgitant losses owing to the prosthetic heart valves. The output of the pneumotachograph is independent of absolute pressure, and so the device may also be used during the systolic (air compression) phase of the cardiac cycle. Analysis of the display of the airflow curves during diastole and systole has great diagnostic value. This device is accurate, easy to calibrate, stable, noninvasive, and does not require modification of any existing air-driven artificial hearts.
气动人工心脏使用一个柔性隔膜将血液与空气隔开。在舒张期,隔膜后面的空气空间与大气相连。舒张期进入心脏的血液将等量的空气排入大气。使用呼吸流速计来检测这种空气流动。气流信号相对于时间的积分得出舒张期排出的空气体积,这等于同一时期进入心脏的血液体积。当在多个心动周期上进行平均时,这个测量的充盈体积等于心输出量。考虑到人工心脏瓣膜的反流损失。呼吸流速计的输出与绝对压力无关,因此该装置也可在心动周期的收缩期(空气压缩)使用。对舒张期和收缩期气流曲线显示的分析具有很大的诊断价值。该装置准确、易于校准、稳定、无创,并且不需要对任何现有的气动人工心脏进行改装。