Stetsenko O N, Poberiĭ I A, Lindner D P
Antibiotiki. 1978 Jan;23(1):74-8.
Tetracycline was administered orally to Shinshilla male rabbits (female, 2.0-2.5 kg) twice a day, the daily dose being 20 mg. The thymus was examined in 1 and 2 weeks by the methods of histo- and cytometry. The reliability of the differences and correlation were estimated by the non-parametric methods. Out of 15 parameters studied 8 showed reliable differences and 5 were statistically connected. The following structural shifts were found: (1) increased numbers of activated and middle thymocytes evident of intraorgan cell activation, (2) higher mitotic index and lower index of the cell degradation resulting in the cortex hypertrophia by the end of the week, (3) increased cell density in the medullar substance which is the morphological criterion of intraorgan migration of the cells from the cortex into the medullar substance. Thus, the morphometric analysis of the thymus proved to be much more informative than the usual morphological analysis. The observed structural change in the thymus is considered to be a result of the antigenic effect of tetracycline on the host.
给新罗雄性兔子（雌性，2.0 - 2.5千克）口服四环素，每日两次，日剂量为20毫克。在第1周和第2周通过组织学和细胞计数方法检查胸腺。采用非参数方法评估差异的可靠性和相关性。在所研究的15个参数中，8个显示出可靠差异，5个具有统计学关联。发现以下结构变化：（1）活化和中等胸腺细胞数量增加，表明器官内细胞活化；（2）有丝分裂指数较高，细胞降解指数较低，导致到周末时皮质肥大；（3）髓质物质中的细胞密度增加，这是细胞从皮质向髓质物质进行器官内迁移的形态学标准。因此，胸腺的形态计量学分析被证明比通常的形态学分析更具信息价值。胸腺中观察到的结构变化被认为是四环素对宿主产生抗原作用的结果。
