血卟啉衍生物及光联合热疗对培养细胞的影响。
Effects of haematoporphyrin derivative and light in combination with hyperthermia on cells in culture.
作者信息
Christensen T, Wahl A, Smedshammer L
出版信息
Br J Cancer. 1984 Jul;50(1):85-9. doi: 10.1038/bjc.1984.142.
Abstract
Interactions between the photodynamic effect of haematoporphyrin derivative and hyperthermia are reported. Cells labelled with haematoporphyrin derivative and irradiated with red light were sensitized by heat, particularly when the cells were heated after the exposure to light. It is shown that there is a synergistic interaction between the photodynamic effect and hyperthermia (42.5 and 45 degrees C). Hyperthermia-induced inhibition of the repair of photodynamic damage is suggested as a mechanism for the interaction. The possibility that these findings may be advantageous to cancer therapy is discussed.
摘要
已报道了血卟啉衍生物的光动力效应与热疗之间的相互作用。用红光照射标记有血卟啉衍生物的细胞时，热会使其致敏，尤其是在光照后加热细胞时。结果表明，光动力效应与热疗（42.5摄氏度和45摄氏度）之间存在协同相互作用。热疗诱导的光动力损伤修复抑制被认为是这种相互作用的一种机制。文中讨论了这些发现可能对癌症治疗有利的可能性。
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