暴露于卟啉并结合光照的人NHIK 3025细胞的增殖
Multiplication of human NHIK 3025 cells exposed to porphyrins in combination with light.
作者信息
Christensen T
出版信息
Br J Cancer. 1981 Sep;44(3):433-9. doi: 10.1038/bjc.1981.202.
Abstract
Cells from the established line NHIK 3025 were exposed to haematoporphyrin derivative and light. After this photodynamic treatment the first interphase of surviving cells was prolonged. Furthermore, a pronounced effect on the progression through the first mitosis was observed. Mainly the duration of metaphase was increased. Some of the cells were irreversibly arrested in mitosis and the cells that were able to complete mitosis after treatment multiplied in the subsequent generations at the same rate as the control. Cells treated in the late stages of the mitosis went out of mitosis at the same rate as the control. This indicates that the treatment with porphyrins and light induces a block in a specific stage of mitosis.
摘要
将已建立的NHIK 3025细胞系的细胞暴露于血卟啉衍生物和光下。经过这种光动力处理后，存活细胞的第一个间期延长。此外，观察到对通过第一次有丝分裂的进程有显著影响。主要是中期的持续时间增加。一些细胞在有丝分裂中不可逆地停滞，而处理后能够完成有丝分裂的细胞在后续代中以与对照相同的速率增殖。在有丝分裂后期处理的细胞以与对照相同的速率退出有丝分裂。这表明卟啉和光处理在有丝分裂的特定阶段诱导了阻滞。
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