人类抗原诱导的抑制作用：通过OKT8 +细胞介导的非特异性抑制
Antigen-induced suppression in man: non-specific suppression mediated via OKT8+ cells.
作者信息
Cohen M G, Munro A J
出版信息
Immunology. 1984 Aug;52(4):589-98.
Abstract
We have developed a simple assay for human peripheral-blood suppressor cells induced by soluble protein antigens. Suppressor cells were obtained from 6-day cultures in the presence of tetanus toxoid or PPD and were assayed in co-cultures with fresh autologous PBLs. The proliferative response in this second culture showed significant suppression varying from 50% to 90%. The suppressor cells are OKT8-positive, resistant to X irradiation and non-specific in their function. They do not impede either the function or production of TCGF in the secondary culture but we are unable to detect a non-specific suppressor factor made by these cells.
摘要
我们已开发出一种针对可溶性蛋白抗原诱导的人外周血抑制细胞的简易检测方法。抑制细胞是在破伤风类毒素或结核菌素纯蛋白衍生物存在的情况下，从6天的培养物中获得的，并与新鲜的自体外周血淋巴细胞在共培养中进行检测。在第二次培养中的增殖反应显示出显著的抑制，抑制率在50%至90%之间。这些抑制细胞OKT8呈阳性，对X射线照射有抗性，其功能是非特异性的。它们在二次培养中既不阻碍白细胞介素-2的功能也不阻碍其产生，但我们无法检测到这些细胞产生的非特异性抑制因子。
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本文引用的文献
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Specific and nonspecific immunoregulatory events in the clonal response of human lymphocytes in vitro.人淋巴细胞体外克隆反应中的特异性和非特异性免疫调节事件。
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Feedback suppression: phenotypes of T cell subsets involved in the Ly1 T cell-induced immunoregulatory circuit.反馈抑制：参与Ly1 T细胞诱导的免疫调节回路的T细胞亚群的表型
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Immunoregulation circa 1980: some comments on the state of the art.1980年前后的免疫调节：对当前技术水平的一些评论。
J Allergy Clin Immunol. 1980 Jul;66(1):18-24. doi: 10.1016/0091-6749(80)90133-5.
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A single major pathway of T-lymphocyte interactions in antigen-specific immune suppression.抗原特异性免疫抑制中T淋巴细胞相互作用的单一主要途径。
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