T8细胞对抗原和丝裂原诱导的T4细胞依赖性免疫球蛋白产生的抑制作用。
T8 cell suppression of antigen- and mitogen-induced T4 cell dependent immunoglobulin production.
作者信息
Nilsson E, von Stedingk L V, Biberfeld G
出版信息
Clin Exp Immunol. 1986 Oct;66(1):150-7.
Abstract
The suppressor effect of T8 cells on antigen-induced, as compared to pokeweed mitogen-induced, T4 cell dependent immunoglobulin (Ig) production by B cells of healthy subjects was studied. The antigens used were purified protein derivative of tuberculin (PPD) and tetanus toxoid (TT). The suppressor effect of T8 cells on IgG, IgM and IgA responses in co-cultures of T4 cells and B cells was significantly stronger in the pokeweed mitogen driven system than in PPD- and TT-driven cultures under the same experimental conditions.
摘要
研究了健康受试者B细胞中，与商陆丝裂原诱导的情况相比，T8细胞对抗原诱导的、T4细胞依赖性免疫球蛋白（Ig）产生的抑制作用。所用抗原为结核菌素纯蛋白衍生物（PPD）和破伤风类毒素（TT）。在相同实验条件下，在商陆丝裂原驱动的系统中，T8细胞对T4细胞和B细胞共培养物中IgG、IgM和IgA反应的抑制作用明显强于PPD和TT驱动的培养物。
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