Rosenbaum R C, Frieri M, Metcalfe D D
J Nucl Med. 1984 Aug;25(8):859-64.
Scintigraphic findings in ten cases of systemic mastocytosis are described. Four radionuclide bone patterns were noted: normal, unifocal, multifocal, and diffuse. Compared with radiographic surveys, bone images were better able to show the widespread skeletal involvement in patients with diffuse disease, and to detect a greater number of focal lesions. Serum calcium, phosphorus, and bone-derived alkaline phosphatase, as well as urinary calcium, phosphorus, and hydroxyproline levels, were usually within normal limits even when the bone scintigrams were clearly abnormal. Plasma and urinary histamine levels were highest in patients whose bone images detected widespread skeletal involvement. In systemic mastocytosis, not only does scintigraphy document active bone disease more effectively than laboratory studies of bone metabolism and radiographs of bone, but it also appears to reflect the general severity of the disease process.
本文描述了10例系统性肥大细胞增多症的闪烁扫描结果。观察到四种放射性核素骨显像模式：正常、单灶性、多灶性和弥漫性。与X线检查相比，骨显像能更好地显示弥漫性疾病患者广泛的骨骼受累情况，并能检测出更多的局灶性病变。即使骨闪烁扫描明显异常，血清钙、磷和骨源性碱性磷酸酶以及尿钙、磷和羟脯氨酸水平通常仍在正常范围内。骨显像显示广泛骨骼受累的患者血浆和尿组胺水平最高。在系统性肥大细胞增多症中，闪烁扫描不仅比骨代谢实验室检查和骨骼X线片更有效地记录活动性骨病，而且似乎还能反映疾病进程的总体严重程度。
