Granerus G, Roupe G
Agents Actions. 1982 Apr;12(1-2):29-31. doi: 10.1007/BF01965102.
The urinary excretion of histamine and its main metabolite, methylimidazoleacetic acid (MelmAA), was determined in 25 adult patients with the clinical diagnosis of urticaria pigmentosa (UP). Extensive clinical and laboratory investigation, including skin histology, bone marrow examination and scintigraphy of skeleton, liver and spleen, implied systemic manifestations in 16 cases. All patients with systemic mastocytosis (SM) excreted abnormal amounts of MelmAA (greater than 4.1 mg/24 h) and most of them 8.0 mg or more per day, while histamine excretion was increased in only nine (greater than 40 microgram/24 h). Thus, the urine content of MelmAA, but not histamine, could differentiate between UP and SM. Severe pruritus was found concomitant with increased urinary MelmAA and indicated systemic mastocytosis.
对25例临床诊断为色素性荨麻疹（UP）的成年患者测定了组胺及其主要代谢产物甲基咪唑乙酸（MelmAA）的尿排泄量。广泛的临床和实验室检查，包括皮肤组织学、骨髓检查以及骨骼、肝脏和脾脏的闪烁扫描，提示16例患者有全身表现。所有系统性肥大细胞增多症（SM）患者的MelmAA排泄量均异常（大于4.1mg/24小时），其中大多数患者每天排泄量达8.0mg或更多，而只有9例患者的组胺排泄量增加（大于40μg/24小时）。因此，MelmAA的尿含量而非组胺含量可区分UP和SM。发现严重瘙痒与尿MelmAA增加相关，提示系统性肥大细胞增多症。
