Kameyama T, Nagasaka M
J Pharmacobiodyn. 1984 Mar;7(3):151-5. doi: 10.1248/bpb1978.7.151.
Mice exhibited marked suppression of motor activity when placed in the same environment where they had previously received electric shocks. Morphine-HCl (20 mg/kg) markedly attenuated such a conditioned suppression in mice. The morphine-induced reduction of the conditioned suppression was antagonized by pretreatment with reserpine (0.1 and 0.5 mg/kg), haloperiodol, pimozide and alpha-methyl-p-tyrosine, but not atropine-sulfate, p-chlorophenylalanine, phenoxybenzamine-HCl or propranolol. Thus, it is possible that the potentiation of the dopaminergic neurotransmission in the brain is involved in the morphine-induced reduction of the conditioned suppression in mice.
当小鼠被置于它们之前遭受过电击的相同环境中时，会表现出明显的运动活动抑制。盐酸吗啡（20毫克/千克）可显著减轻小鼠的这种条件性抑制。吗啡诱导的条件性抑制的减轻被利血平（0.1和0.5毫克/千克）、氟哌啶醇、匹莫齐特和α-甲基-对-酪氨酸预处理所拮抗，但硫酸阿托品、对氯苯丙氨酸、盐酸酚苄明或普萘洛尔则无此作用。因此，大脑中多巴胺能神经传递的增强可能参与了吗啡诱导的小鼠条件性抑制的减轻。
