匹莫齐特、氟哌啶醇、α-甲基对酪氨酸和利血平对大鼠吗啡依赖性形成的影响。

The influence of pimozide, haloperidol, alpha-methyl-p-tyrosine and reserpine on the development of morphine dependence in rats.

作者信息

Kruszewska A, Langwiński R

出版信息

Drug Alcohol Depend. 1983 Jun;11(3-4):383-8. doi: 10.1016/0376-8716(83)90029-7.

DOI:10.1016/0376-8716(83)90029-7

Abstract

It was found that pimozide, haloperidol and alpha-methyl-p-tyrosine (alpha-MT), drugs inhibiting central catecholaminergic (CA) transmission, increased the development of morphine dependence measured as wet dog shakes in rats. Reserpine inhibiting CA and serotoninergic (5-HT) transmission, decreased the development of morphine dependence in rats. The inhibitory effect of reserpine was reversed by 5-hydroxytryptophan (5-HTP), but not by L-dihydroxyphenylalanine (L-DOPA). These results suggest that wet dog shakes might develop as a result of regulatory adaptation in the 5-HT neurotransmitter system.

摘要

研究发现，匹莫齐特、氟哌啶醇和α-甲基对酪氨酸（α-MT）这些抑制中枢儿茶酚胺能（CA）传递的药物，会增加以大鼠湿狗样抖动来衡量的吗啡依赖性的发展。利血平抑制CA和5-羟色胺能（5-HT）传递，会降低大鼠吗啡依赖性的发展。5-羟色氨酸（5-HTP）可逆转利血平的抑制作用，但左旋多巴（L-DOPA）则不能。这些结果表明，湿狗样抖动可能是5-HT神经递质系统调节适应的结果。

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