Antel J P, Rosenkoetter M, Reder A, Oger J J, Arnason B G
Neurology. 1984 Sep;34(9):1155-60. doi: 10.1212/wnl.34.9.1155.
The proportion of MS patients whose pokeweed mitogen-stimulated mononuclear cells (MNCs) secreted greater than 1,000 ng/ml IgG per 10(6) cells (ie, "high responders") was increased compared with controls. The suppressor effect mediated by a constant number of T8+ cells from high responders, both MS and control, on IgG secretion by standard T helper (T4+) plus B-cell cultures was significantly lower than that for the same number of T8+ cells from "low responders." The proportion of T8+ cells within MNCs from MS patients did not correlate with levels of IgG secretion. Our results indicate that high levels of IgG secretion by MNCs, an occurrence overrepresented in the MS population, is significantly influenced by functional properties of T suppressor cells.
与对照组相比，美洲商陆有丝分裂原刺激的单核细胞（MNCs）每10⁶细胞分泌超过1000 ng/ml IgG的多发性硬化症（MS）患者比例有所增加。来自MS患者和对照组的高反应者中恒定数量的T8⁺细胞对标准T辅助（T4⁺）加B细胞培养物中IgG分泌的抑制作用明显低于来自“低反应者”的相同数量T8⁺细胞的抑制作用。MS患者MNCs中T8⁺细胞的比例与IgG分泌水平无关。我们的结果表明，MNCs高水平的IgG分泌（在MS人群中这种情况过度存在）受到T抑制细胞功能特性的显著影响。
