Marrosu M G, Cianchetti C, Ennas M G
Ital J Neurol Sci. 1986 Feb;7(1):101-5. doi: 10.1007/BF02230426.
T3+ (all-T) and T8+ (suppressor/cytotoxic) cells were studied in cerebrospinal fluid (CSF) from 24 patients with multiple sclerosis (MS) and from 24 subjects with various "non-immunological" disease (NID). MS patients were classed as (a) during the acute phase of the 1st episode of the disease, (b) in acute relapse, (c) with chronic progressive disease, (d) with increased or (e) normal CSF IgG content or (f) with neurological impairment (Kurtzke scale) less than or equal to 3 or (g) greater than 3. In MS cases considered as a whole a significant decrease in CSF T3+ cells was found compared to NID patients. When single groups were considered, T3+ cells decrease was significant in classes (b), (d) and (f). Significantly lower percentages of T8+ cells, compared to NID, were found in MS classes (a), (d) and (f).
对24例多发性硬化症（MS）患者和24例患有各种“非免疫性”疾病（NID）的受试者的脑脊液（CSF）中的T3 +（全T）细胞和T8 +（抑制/细胞毒性）细胞进行了研究。MS患者被分类为：（a）疾病首次发作的急性期；（b）急性复发期；（c）慢性进行性疾病；（d）脑脊液IgG含量增加；（e）脑脊液IgG含量正常；（f）神经功能障碍（Kurtzke量表）小于或等于3；（g）大于3。总体来看，与NID患者相比，MS患者脑脊液中的T3 +细胞显著减少。当单独考虑各个组时，（b）、（d）和（f）组的T3 +细胞减少显著。与NID相比，MS的（a）、（d）和（f）组中T8 +细胞的百分比显著降低。
