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汞-硒化合物与汞化合物对培养细胞的细胞毒性比较。

Comparison of cytotoxicity of mercury-selenium and mercury compounds on cultured cells.

作者信息

Mochizuki Y, Kobayashi T, Doi R

出版信息

Toxicol Lett. 1984 Jul;22(1):47-51. doi: 10.1016/0378-4274(84)90044-4.

DOI:10.1016/0378-4274(84)90044-4
PMID:6235624
Abstract

In vitro effects of mercury-selenium (Hg-Se) compounds, as compared with their original mercury compounds, against growth and viability of HeLa cells were studied. A water-soluble, ethanol-insoluble black complex (GX) formed from HgCl2, Na2SeO3 and GSH was less toxic than HgCl2, but the cytotoxicity of bis(methylmercuric) selenide (BMS) seemed to be similar to that of methylmercury. This may be due to the instability of BMS; i.e., there is a possibility that BMS decomposed to methylmercury and selenium under our culture conditions.

摘要

研究了汞 - 硒(Hg - Se)化合物与其原始汞化合物相比,对HeLa细胞生长和活力的体外影响。由HgCl2、Na2SeO3和GSH形成的一种水溶性、乙醇不溶性黑色复合物(GX)的毒性低于HgCl2,但二甲基汞硒化物(BMS)的细胞毒性似乎与甲基汞相似。这可能是由于BMS的不稳定性;即,在我们的培养条件下,BMS有可能分解为甲基汞和硒。

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