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汞-硒化合物对酶的体外作用。

In vitro effects of mercury-selenium compounds on enzymes.

作者信息

Mochizuki Y, Kobayashi T, Doi R

出版信息

Toxicol Lett. 1982 Dec;14(3-4):201-6. doi: 10.1016/0378-4274(82)90052-2.

DOI:10.1016/0378-4274(82)90052-2
PMID:7167980
Abstract

In vitro effects of mercury-selenium compounds, as compared with mercurials, against glucose-6-phosphate dehydrogenase (G6PD), catalase and trypsin were studied. Inhibitory potencies of two mercury-selenium (Hg-Se) compounds, bis(methylmercuric) selenide (BMS), and a reaction product of HgCl2, Na2SeO3 and glutathione (GSH), were markedly weaker than those of their original mercurials, methylmercury and mercuric mercury, respectively.

摘要

研究了汞 - 硒化合物与汞制剂相比,对葡萄糖 - 6 - 磷酸脱氢酶(G6PD)、过氧化氢酶和胰蛋白酶的体外作用。两种汞 - 硒(Hg - Se)化合物,即双(甲基汞)硒化物(BMS)以及HgCl2、Na2SeO3和谷胱甘肽(GSH)的反应产物,其抑制效力分别明显弱于它们各自原来的汞制剂,即甲基汞和汞。

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In vitro effects of mercury-selenium compounds on enzymes.汞-硒化合物对酶的体外作用。
Toxicol Lett. 1982 Dec;14(3-4):201-6. doi: 10.1016/0378-4274(82)90052-2.
2
Comparison of cytotoxicity of mercury-selenium and mercury compounds on cultured cells.汞-硒化合物与汞化合物对培养细胞的细胞毒性比较。
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引用本文的文献

1
The influence of nutrition on methyl mercury intoxication.营养对甲基汞中毒的影响。
Environ Health Perspect. 2000 Mar;108 Suppl 1(Suppl 1):29-56. doi: 10.1289/ehp.00108s129.