汞-硒化合物对酶的体外作用。

In vitro effects of mercury-selenium compounds on enzymes.

作者信息

Mochizuki Y, Kobayashi T, Doi R

出版信息

Toxicol Lett. 1982 Dec;14(3-4):201-6. doi: 10.1016/0378-4274(82)90052-2.

Abstract

In vitro effects of mercury-selenium compounds, as compared with mercurials, against glucose-6-phosphate dehydrogenase (G6PD), catalase and trypsin were studied. Inhibitory potencies of two mercury-selenium (Hg-Se) compounds, bis(methylmercuric) selenide (BMS), and a reaction product of HgCl2, Na2SeO3 and glutathione (GSH), were markedly weaker than those of their original mercurials, methylmercury and mercuric mercury, respectively.

摘要

研究了汞 - 硒化合物与汞制剂相比，对葡萄糖 - 6 - 磷酸脱氢酶（G6PD）、过氧化氢酶和胰蛋白酶的体外作用。两种汞 - 硒（Hg - Se）化合物，即双（甲基汞）硒化物（BMS）以及HgCl2、Na2SeO3和谷胱甘肽（GSH）的反应产物，其抑制效力分别明显弱于它们各自原来的汞制剂，即甲基汞和汞。