Shandra A A, Kryzhanovskiĭ G N
Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84(6):899-903.
The effects of synthetic antiepileptic drugs (phenobarbital and diazepam) and vitamins (nicotinamide, pyridoxal-5 phosphate and alpha-tocopherol) were investigated on the model of the chronically epileptized brain in the form of corasole kindling in inbred and noninbred mice. It has been shown that both series of drugs inhibit the epileptic activity developing at the peak of brain epileptization and prevent its further development. The results of the study demonstrate the benefit of the multimodality pathogenetic therapy of epilepsy and suggest the advisability of its practical application.
研究了合成抗癫痫药物（苯巴比妥和地西泮）以及维生素（烟酰胺、磷酸吡哆醛和α-生育酚）对近交系和非近交系小鼠中以科拉索尔点燃形式建立的慢性癫痫化脑模型的影响。结果表明，这两类药物均能抑制在脑癫痫化高峰期发展的癫痫活动，并阻止其进一步发展。该研究结果证明了癫痫多模式发病机制治疗的益处，并表明其实际应用的可取性。
