Kryzhanovskiĭ G N, Shandra A A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1981;81(6):801-9.
In experiments on cats it was shown that nicotinamide injected intravenously in a dose of 300 to 500 mg per kg body weight depressed singular epileptic foci and groups of foci with synchronized activity induced in the animals' brain cortex by application of strychnine (0.1 ml of 3% solution). The vitamin was also effective, though to a lesser degree, in depressing foci induced by application of penicillin (2% solution). Pyridoxal-5-phosphate (Pyr-5-Ph) injected intravenously in a dose of 10 mg/kg depressed singular foci and groups of foci with synchronized activity induced by application of 2% solution of penicillin, but was less effective in depressing strychnine-induced foci. Combined application of both drugs even in lower doses (nicotinamide, 200 mg/kg; Pyr-5-Ph, 5 mg/kg) resulted in depression of groups of epileptic foci induced by combined application of strychnine and penicillin. Mechanisms of the effects discovered are discussed. A question on possible use of combined nicotinamide and pyridoxal-5-phosphate in the treatment of epilepsy is raised.
在猫的实验中表明，以每千克体重300至500毫克的剂量静脉注射烟酰胺，可抑制由士的宁（0.1毫升3%溶液）在动物大脑皮层诱发的单个癫痫病灶以及具有同步活动的病灶群。该维生素在抑制由青霉素（2%溶液）诱发的病灶方面也有效果，不过程度较小。以每千克体重10毫克的剂量静脉注射磷酸吡哆醛（Pyr - 5 - Ph），可抑制由2%青霉素溶液诱发的单个病灶以及具有同步活动的病灶群，但在抑制士的宁诱发的病灶方面效果较差。两种药物联合应用，即使是较低剂量（烟酰胺，200毫克/千克；Pyr - 5 - Ph，5毫克/千克），也能抑制由士的宁和青霉素联合应用诱发的癫痫病灶群。文中讨论了所发现效应的机制。还提出了关于联合使用烟酰胺和磷酸吡哆醛治疗癫痫的可能性问题。
