纤维蛋白溶解在周围血管疾病治疗中的作用。
The role of fibrinolysis in the therapy of peripheral vascular disease.
作者信息
Ambrus C M, Ambrus J L, Gastpar H, Sharma S D, Suh O W, Moore R H, Williams P
出版信息
Angiology. 1984 Jul;35(7):436-42. doi: 10.1177/000331978403500706.
PMID:6235758
Abstract
In vivo thrombolytic studies in stumptailed monkeys indicated that pentoxifylline potentiates thrombolysis induced by urokinase activated human plasmin. Pentoxifylline as well as prostaglandin E1 released plasminogen activators and activated the fibrinolysin system. From this point of view pentoxifylline and prostaglandin E1 synergized with each other. Pentoxifylline potentiated the thrombolytic effect of prostaglandin E1 in vivo.
摘要
对短尾猴进行的体内溶栓研究表明，己酮可可碱可增强尿激酶激活的人纤溶酶所诱导的溶栓作用。己酮可可碱以及前列腺素E1均可释放纤溶酶原激活剂并激活纤溶系统。从这一角度来看，己酮可可碱与前列腺素E1具有协同作用。己酮可可碱可增强前列腺素E1在体内的溶栓效果。
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