Stern R S, Bigby M
JAMA. 1984 Sep 21;252(11):1433-7.
The nonsteroidal anti-inflammatory drugs are widely used in the United States and are a frequent cause of cutaneous reactions. Since December 1980, dermatologists have reported 135 of these drug reactions to a specialty-based Adverse Drug Reaction Reporting System. Reactions to piroxicam were most frequently reported; the majority of reactions to this drug were vesiculobullous and occurred most often in sun-exposed areas. Other reactions to nonsteroidal anti-inflammatory drugs not previously recognized include serum sickness, exfoliative erythroderma, and photosensitivity associated with sulindac; toxic epidermal necrolysis was reported with tolmetin, zomepirac sodium, and piroxicam. Fixed drug eruptions were noted with ibuprofen and naproxen, and photosensitivity was reported with sulindac and indomethacin. These findings illustrate the usefulness of a specialty-based system for spontaneous reporting of new and serious adverse reactions to drugs.
非甾体抗炎药在美国广泛使用，是皮肤反应的常见原因。自1980年12月以来，皮肤科医生已向一个基于专业的药物不良反应报告系统报告了135例此类药物反应。对吡罗昔康的反应报告最为频繁；对该药物的大多数反应为水疱大疱性，且最常发生在暴露于阳光下的部位。其他以前未被认识到的对非甾体抗炎药的反应包括血清病、剥脱性红皮病以及与舒林酸相关的光敏反应；据报告，托美汀、佐美酸钠和吡罗昔康可引起中毒性表皮坏死松解症。布洛芬和萘普生可引起固定性药疹，舒林酸和吲哚美辛可引起光敏反应。这些发现说明了基于专业的系统对于自发报告药物新的严重不良反应的有用性。
