Bigby M, Stern R
J Am Acad Dermatol. 1985 May;12(5 Pt 1):866-76. doi: 10.1016/s0190-9622(85)70110-7.
The nonsteroidal anti-inflammatory drugs are one of the most commonly prescribed classes of drugs used in medical practice. This review discusses the diverse cutaneous reactions associated with nonsteroidal anti-inflammatory drugs. Adverse cutaneous reactions occur most frequently with benoxaprofen, piroxicam, sulindac, meclofenamate sodium, zomepirac sodium, and phenylbutazone. The most serious adverse cutaneous reactions, Stevens-Johnson syndrome and toxic epidermal necrolysis, appear to be most often associated with sulindac and phenylbutazone. Tolmetin and zomepirac sodium, two structurally similar pyrrole derivatives, have been associated with a disproportionate number of cases of anaphylactoid reactions. Among the currently marketed nonsteroidal anti-inflammatory drugs, piroxicam appears to have the highest rate of phototoxic reactions. This phototoxic eruption is most often vesiculobullous.
非甾体抗炎药是医学实践中最常用的处方药类别之一。本综述讨论了与非甾体抗炎药相关的各种皮肤反应。皮肤不良反应最常发生于苯恶洛芬、吡罗昔康、舒林酸、甲氯芬那酸钠、佐美酸钠和保泰松。最严重的皮肤不良反应，即史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症，似乎最常与舒林酸和保泰松相关。托美丁和佐美酸钠这两种结构相似的吡咯衍生物，与不成比例数量的类过敏反应病例有关。在目前市场上销售的非甾体抗炎药中，吡罗昔康似乎具有最高的光毒性反应发生率。这种光毒性皮疹最常为水疱大疱性。
