Dintzis H M, Dintzis R Z, Vogelstein B
Proc Natl Acad Sci U S A. 1976 Oct;73(10):3671-5. doi: 10.1073/pnas.73.10.3671.
The immunological response in vivo to a series of size-fractionated linear polymers of acrylamide substituted with hapten has been measured in mice. A sharp threshold was observed in immunogenic response elicited by various polymer preparations. All polymers with less than 12 to 16 appropriately spaced hapten groups per molecule were nonimmunogenic, while those polymers with greater than this number were fully immunogenic. The results lead to the conclusion that the immunological response at its most elementary level is quantized, i.e., a minimum specific number of antigen receptors (approximately 12 to 16) must be connected together as a spatially continuous cluster, an immunon, before an immunogenic signal is delivered to the responding cell.
在小鼠体内测量了对一系列用半抗原取代的丙烯酰胺大小分级线性聚合物的免疫反应。在各种聚合物制剂引发的免疫原性反应中观察到了一个明显的阈值。所有每分子具有少于12至16个适当间隔的半抗原基团的聚合物都是无免疫原性的，而那些具有大于此数量的聚合物则是完全免疫原性的。结果得出结论，免疫反应在其最基本水平是量子化的，即，在免疫原性信号传递到反应细胞之前，最小特定数量的抗原受体（约12至16个）必须作为空间连续簇（免疫单位）连接在一起。
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