Lemm G, Warnatz H
Z Rheumatol. 1984 May-Jun;43(3):106-12.
Seronegative rheumatoid arthritis (RA) patients have increased proportions of OKT-4+ (helper) T cells and diminished proportions of OKT-8+ (suppressor/cytotoxic) T cells in the peripheral blood. This phenomenon corresponds to diminished inhibition of B cell activation by peripheral blood lymphocytes (PBL). Seropositive RA patients show a broad range of OKT-8+ T cell proportions (9%-45%) in the peripheral blood, resulting in a mean level comparable to that in controls. Inhibition of T cell activation by suppressor cells in peripheral blood is greater in this group than in controls. HLA-B27-positive arthritis patients show no significant differences from controls with respect to markers and functional suppressor cell assays. In the synovial fluid of all patients both OKT-8+ T cell proportions and functional suppressor cell activity are greatly increased.
血清阴性类风湿性关节炎（RA）患者外周血中OKT-4 +（辅助性）T细胞比例增加，而OKT-8 +（抑制性/细胞毒性）T细胞比例减少。这种现象与外周血淋巴细胞（PBL）对B细胞活化的抑制作用减弱相对应。血清阳性RA患者外周血中OKT-8 + T细胞比例范围较广（9% - 45%），导致其平均水平与对照组相当。该组外周血中抑制性细胞对T细胞活化的抑制作用比对照组更强。HLA - B27阳性关节炎患者在标志物和功能性抑制性细胞检测方面与对照组无显著差异。在所有患者的滑液中，OKT-8 + T细胞比例和功能性抑制性细胞活性均大幅增加。
