Bugajski J, Gadek A
Agents Actions. 1984 Jun;14(5-6):569-73. doi: 10.1007/BF01978888.
In the rats subjected to a mild stress of immobilization impromidine, and H2-receptor agonist, given 60 min prior to the stress, intensified the stress-induced increase in hypophyseal-adrenocortical response, evaluated indirectly through the corticosterone concentration in the blood serum. Impromidine was far more potent but only about half as efficient as histamine, 4-methyl histamine (4-MH) and dimaprit. The effect of impromidine was abolished by pretreatment of the rats with cimetidine. The alpha-adrenergic blockers phenoxybenzamine, phentolamine and yohimbine, almost totally antagonized the corticosterone response to impromidine in stressed rats. Propranolol, a beta-adrenergic blocker, abolished the corticosterone response to impromidine but did not antagonize the response to 4-MH and dimaprit. The effect of impromidine was not modified by i.c.v. pretreatment of the rats with atropine. The results obtained show that impromidine is far more potent but less efficient than histamine and the previously known selective H2-receptor agonists in inducing the pituitary-adrenocortical response in stressed rats. These results also suggest that impromidine may release norepinephrine but not interact with cholinergic receptors while stimulating the corticosterone response in stressed rats.
在遭受轻度制动应激的大鼠中，在应激前60分钟给予H2受体激动剂英普咪定，可增强通过血清皮质酮浓度间接评估的应激诱导的垂体 - 肾上腺皮质反应增强。英普咪定的效力远高于组胺、4 - 甲基组胺（4 - MH）和二甲双胍，但效率仅约为它们的一半。用西咪替丁预处理大鼠可消除英普咪定的作用。α - 肾上腺素能阻滞剂酚苄明、酚妥拉明和育亨宾几乎完全拮抗应激大鼠对英普咪定的皮质酮反应。β - 肾上腺素能阻滞剂普萘洛尔消除了对英普咪定的皮质酮反应，但不拮抗对4 - MH和二甲双胍的反应。用阿托品对大鼠进行脑室内预处理不会改变英普咪定的作用。所得结果表明，在诱导应激大鼠的垂体 - 肾上腺皮质反应方面，英普咪定的效力远高于组胺和先前已知的选择性H2受体激动剂，但效率较低。这些结果还表明，英普咪定可能释放去甲肾上腺素，但在刺激应激大鼠的皮质酮反应时不与胆碱能受体相互作用。
