Lebrault C, Lavaud E, Strumza P, Nebout T, Duvaldestin P
Ann Fr Anesth Reanim. 1984;3(4):273-6. doi: 10.1016/s0750-7658(84)80119-7.
The muscle relaxant effect of atracurium was monitored by measuring the strength of the adductor pollicis muscle (TH) elicited by supramaximal stimulation of the ulnar nerve at the wrist. In order to facilitate tracheal intubation, a dose of 0.6 mg X kg-1 was administered in 10 patients with complete renal failure. The results were compared with those obtained from 20 normal patients. The dose of 0.6 mg X kg-1 produced adequate conditions for tracheal intubation. A 95% or more depression of TH was obtained in both groups after 3 min. The duration of effect was similar in both groups. The delay between injection and 75% recovery of TH was of 62 min in controls and 52 min in patients with renal failure. Only the recovery index (the time elapsed between 25% and 75% recovery) was shorter in patients with renal failure (p less than 0.01): 8 min instead of 14 min in the controls.
通过测量腕部尺神经超最大刺激引起的拇内收肌（TH）的肌力来监测阿曲库铵的肌肉松弛作用。为便于气管插管，对10例完全肾衰竭患者给予0.6mg·kg⁻¹的剂量。将结果与20例正常患者的结果进行比较。0.6mg·kg⁻¹的剂量产生了足够的气管插管条件。3分钟后两组的TH均出现95%或更高的抑制。两组的作用持续时间相似。对照组注射至TH恢复75%的延迟时间为62分钟，肾衰竭患者为52分钟。只有肾衰竭患者的恢复指数（从25%恢复到75%所用的时间）较短（p<0.01）：对照组为14分钟，而肾衰竭患者为8分钟。
