Herrera J, Montalvo I, González Garza M T, Sotelo A, Gómez S, Bermúdez J A
Arch Androl. 1984;12(1):53-8. doi: 10.3109/01485018409161149.
Suppression of the testicular T production by effect of the CSF has been previously reported. Changes in the testicular content of intermediates and precursors of T biosynthesis were determined in rats fed during 28 days with diets containing 25,35 and 50% of CSF and compared with a defated cottonseed flour diet group and a control Purina-chow diet group. Also described were modifications during a six wk post CSF diet period. The results showed a diminution in pregnenolone and progesterone testicular content to a third and a half of the control values (21.5 and 19.3 pg/mg of protein respectively). Other compounds in the delta 5 pathway, 17 hidroxypregnenolone and dehydroepiandrosterone were undetectable since the 35% CSF diet, the 17 hidroxyprogesterone diminished to undetectable values only with the maximal (50%) CSF content diet. During the post CSF diet period all the steroids showed a tendency toward the control values. The 25% CSF content diet group reached the initial contents; other groups presented different recovery degrees. The most affected was the 50% diet group with a direct effect of the CSF on the testicular androgen steroidogenesis affecting both the delta 4 and the delta 5 pathways.
先前已有报道称脑脊液（CSF）会抑制睾丸睾酮（T）的生成。对食用含25%、35%和50%脑脊液的饲料28天的大鼠，测定其睾丸中T生物合成中间产物和前体的含量变化，并与食用脱脂棉籽粉饲料组和对照普瑞纳饲料组进行比较。还描述了在停用含脑脊液饲料后的六周期间的变化情况。结果显示，孕烯醇酮和孕酮的睾丸含量降至对照值的三分之一和二分之一（分别为21.5和19.3 pg/mg蛋白质）。自35%脑脊液饲料组起，5途径中的其他化合物，17-羟孕烯醇酮和脱氢表雄酮无法检测到，17-羟孕酮仅在脑脊液含量最高（50%）的饲料组中降至无法检测的值。在停用含脑脊液饲料期间，所有类固醇都呈现出接近对照值的趋势。25%脑脊液含量饲料组恢复到初始含量；其他组呈现出不同的恢复程度。受影响最大的是50%饲料组，脑脊液对睾丸雄激素类固醇生成有直接影响，同时影响4途径和5途径。
