Herrera J, Montalvo I, González-Garza M T, Sotelo A, Bermúdez J A
Arch Androl. 1983 Oct;11(2):161-5. doi: 10.3109/01485018308987476.
Natural gossypol present in the whole cottonseed flour (CSF) has clear antifertility properties, decreasing the number and motility of spermatozoa. In this study the endocrine function of the testes was evaluated, measuring by specific radioimmunoassays the testicular content and the serum levels of androstenedione (A), testosterone (T), and 5 alpha-dihydrotestosterone in male rats fed with different and nontoxic concentrations of CSF along with Purina chow for 4 weeks, followed by 6 weeks of a recovery period. The testicular content of A, T, and DHT decreased 63%, 90%, and 38%, respectively, in comparison with their control. The serum levels of the three androgens diminished as follows: A 74%, T 95%, and DHT 60%. All the steroids measured in the recovery period showed a tendency towards the control values in both testicular content and serum. The most affected steroid was testosterone, which, after the recovery period, did not reach the control values. A also decreased, suggesting a blockade in testicular steroidogenesis caused by the initial diet.
全棉籽粉（CSF）中含有的天然棉酚具有明确的抗生育特性，可减少精子数量和活力。在本研究中，通过特定放射免疫测定法，对喂食不同无毒浓度CSF并搭配普瑞纳饲料4周、随后有6周恢复期的雄性大鼠，评估其睾丸的内分泌功能，测量睾丸中雄烯二酮（A）、睾酮（T）和5α-二氢睾酮的含量以及血清水平。与对照组相比，睾丸中A、T和双氢睾酮（DHT）的含量分别下降了63%、90%和38%。三种雄激素的血清水平下降情况如下：A下降74%，T下降95%，DHT下降60%。在恢复期测量的所有类固醇在睾丸含量和血清方面均显示出接近对照值的趋势。受影响最大的类固醇是睾酮，恢复期后其未达到对照值。A也有所下降，表明初始饮食导致睾丸类固醇生成受阻。
