高剂量醋酸甲羟孕酮（MPA）治疗期间淋巴细胞的体外功能
In vitro functions of lymphocytes during high-dose medroxyprogesterone acetate (MPA) treatment.
作者信息
Grönroos M, Eskola J
出版信息
Cancer Immunol Immunother. 1984;17(3):218-20. doi: 10.1007/BF00205489.
Abstract
The number and function of T and B lymphocytes were studied in endometrial cancer patients during 3 months' treatment with high-dose medroxyprogesterone acetate (MPA). No significant changes were observed in the proportions of T and B cells or in the function of B cells during MPA treatment. At 3 months, lymphocyte blastogenic responsiveness to mitogens was slightly reduced both in patients treated with standard therapy alone (intracavitary radium and surgery) and in patients receiving additional MPA therapy. These results indicate that other factors than progesterone are responsible for the suppression of lymphocyte blastogenesis induced by mitogens during high-dose progestin treatment.
摘要
对子宫内膜癌患者在接受大剂量醋酸甲羟孕酮（MPA）治疗的3个月期间的T淋巴细胞和B淋巴细胞数量及功能进行了研究。在MPA治疗期间，T细胞和B细胞的比例以及B细胞的功能均未观察到显著变化。在3个月时，单独接受标准治疗（腔内镭疗和手术）的患者以及接受额外MPA治疗的患者，其淋巴细胞对有丝分裂原的增殖反应性均略有降低。这些结果表明，在大剂量孕激素治疗期间，除孕酮外的其他因素是导致有丝分裂原诱导的淋巴细胞增殖受抑制的原因。
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本文引用的文献
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