枯草芽孢杆菌DSM704的特性及其1-脱氧野尻霉素的生产
Characterization of Bacillus subtilis DSM704 and its production of 1-deoxynojirimycin.
作者信息
Stein D C, Kopec L K, Yasbin R E, Young F E
出版信息
Appl Environ Microbiol. 1984 Aug;48(2):280-4. doi: 10.1128/aem.48.2.280-284.1984.
Abstract
A Bacillus subtilis strain, DSM704, was characterized by genetic means, and its production of a human intestinal sucrase inhibitor, 1-deoxynojirimycin, was described. Synthesis of this compound is detected concomitant with the detection of heat-resistant spores. The amount of 1-deoxynojirimycin produced is highly dependent on the carbon source, with growth on substrates metabolized via glycolysis giving the greatest amount of production (up to 1 mg/ml). 1-Deoxynojirimycin appears to be nonmetabolizable by the producing strain in that it cannot serve as a sole carbon or nitrogen source.
摘要
对一株枯草芽孢杆菌DSM704进行了遗传学特征分析，并描述了其产生人肠道蔗糖酶抑制剂1-脱氧野尻霉素的情况。该化合物的合成与耐热孢子的检测同时被发现。1-脱氧野尻霉素的产量高度依赖于碳源，在通过糖酵解代谢的底物上生长时产量最高（可达1毫克/毫升）。1-脱氧野尻霉素似乎不能被产生菌株代谢，因为它不能作为唯一的碳源或氮源。
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