Facchetti F, de Wolf-Peeters C, de Greef H, Desmet V J
Arch Dermatol Res. 1984;276(5):283-7. doi: 10.1007/BF00404618.
We used immunohistochemistry to study Langerhans cells (LCs) and the composition of the dermal inflammatory infiltrate both in normal skin and in biopsies from various benign and malignant pigment-cell lesions. In normal skin and most benign pigment-cell lesions, epidermal LCs are regularly distributed. OKT6-Positive cells outnumber the OKIa-positive cells. The inconspicuous dermal infiltrate studied in these biopsies was composed of helper and suppressor/cytotoxic T cells and some dermal LCs. More epidermal LCs with an abnormal cytologic presentation were found in a halo naevus and in the radial growth part of primary malignant melanomas. This finding was associated with a dermal infiltrate composed of suppressor/cytotoxic T cells, suggesting a defense mechanism of the host towards abnormal melanocytes. Epidermal LCs were rare in the central part of the biopsies which showed a primary malignant melanoma in its vertical growth. A dermal inflammatory infiltrate was absent in that area. These findings are interpreted as the morphologic expression of a damaged immune system.
我们采用免疫组织化学方法研究了正常皮肤以及各种良性和恶性色素细胞病变活检组织中朗格汉斯细胞（LCs）和真皮炎症浸润的组成。在正常皮肤和大多数良性色素细胞病变中，表皮LCs呈规则分布。OKT6阳性细胞数量多于OKIa阳性细胞。这些活检组织中不明显的真皮浸润由辅助性T细胞、抑制性/细胞毒性T细胞和一些真皮LCs组成。在晕痣和原发性恶性黑色素瘤的放射状生长部分发现了更多具有异常细胞学表现的表皮LCs。这一发现与由抑制性/细胞毒性T细胞组成的真皮浸润有关，提示宿主对异常黑素细胞的防御机制。在垂直生长的原发性恶性黑色素瘤活检组织中央部分，表皮LCs很少见。该区域无真皮炎症浸润。这些发现被解释为免疫系统受损的形态学表现。
