通过给予第二剂疫苗，可以克服母体对小鼠疟疾疫苗接种的抑制作用。
Maternal inhibition of malaria vaccination in mice can be overcome by giving a second dose of vaccine.
作者信息
Harte P G, Rogers N, Targett G A, Playfair J H
出版信息
Immunology. 1984 Nov;53(3):401-9.
Abstract
A single dose of a formalin-fixed malaria vaccine which normally protects mice against challenge with the live parasite, is ineffective in mice born to immune mothers. This inhibition of protection, which is due to maternally-derived IgG, can be overcome if a second dose of vaccine is given 10 or more days after the first. We show that this is related to the production of specific IgM antibody in response to the first dose of vaccine, which competitively blocks the inhibitory effect of the IgG. The implications of this finding in relation to immune regulation and immunization regimes are discussed.
摘要
一剂通常能保护小鼠免受活寄生虫攻击的福尔马林固定疟疾疫苗，对免疫母鼠所生的小鼠无效。这种保护作用的抑制是由母体来源的IgG引起的，如果在第一剂疫苗接种10天或更长时间后再接种第二剂疫苗，这种抑制作用可以被克服。我们表明，这与对第一剂疫苗产生的特异性IgM抗体有关，该抗体竞争性地阻断了IgG的抑制作用。本文讨论了这一发现对免疫调节和免疫方案的意义。
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Response of infants to a third dose of poliomyelitis vaccine given 10 to 12 months after primary immunization.婴儿在初次免疫后10至12个月接种第三剂脊髓灰质炎疫苗的反应。
Br Med J. 1959 Mar 14;1(5123):680-2. doi: 10.1136/bmj.1.5123.680.
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Antibody mediated regulation of immune responses. I. Enhancement of specific antibody responses through IgM antibodies.
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The role of T cells in regulating immunoglobulin class and subclass.T细胞在调节免疫球蛋白类别和亚类中的作用。
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Specific monoclonal IgM is a potent adjuvant in murine malaria vaccination.特异性单克隆IgM在鼠疟疫苗接种中是一种有效的佐剂。
Nature. 1983;302(5905):256-8. doi: 10.1038/302256a0.
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T cell regulation of isotype expression. The requirement for a second Ig-specific helper T cell population for the induction of IgG responses.T细胞对抗体类型表达的调节。诱导IgG应答需要第二种Ig特异性辅助性T细胞群体。
Eur J Immunol. 1981 Sep;11(9):705-10. doi: 10.1002/eji.1830110907.
6
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7
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