Brittle M P, Playfair J H
Immunology. 1980 Nov;41(3):743-52.
A plaque-forming cell assay was used to follow the changes in Ig class and subclass during the response of mice to repeated injections of sheep red cells. The proportion of IgG1 rose, and that of IgG2b fell, as the response proceeded. In cell-transfer experiments both B and T cells displayed this tendency, and when asynchronously primed cells co-operated together, the pattern was characteristic of the longer-primed population. Thus T cells can advance, but cannot reverse, the progress of isotype changes in B cells. Evidence is presented for two physically separable T-cell subpopulations which need to interact in order the help B cells produce certain isotypes.
采用空斑形成细胞试验来追踪小鼠对反复注射绵羊红细胞产生应答过程中免疫球蛋白（Ig）类别和亚类的变化。随着应答的进行，IgG1的比例上升，而IgG2b的比例下降。在细胞转移实验中，B细胞和T细胞均表现出这种趋势，并且当不同步致敏的细胞协同作用时，其模式具有较长时间致敏群体的特征。因此，T细胞可以促进但不能逆转B细胞同种型变化的进程。本文提供了证据，表明存在两个物理上可分离的T细胞亚群，它们需要相互作用才能帮助B细胞产生某些同种型。
