秋水仙碱对健康志愿者T细胞亚群的影响。

Effect of colchicine on T cell subsets of healthy volunteers.

作者信息

Ilfeld D, Feierman E, Kuperman O, Kivity S, Topilsky M, Netzer L, Pecht M, Trainin N

出版信息

Immunology. 1984 Nov;53(3):595-8.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1454916/

Abstract

We examined the effect of oral colchicine (1-2 mg/day) on four healthy volunteers' T cell subsets. Colchicine significantly (P less than 0.01) decreased the mean (+/- SD) percent of OKT3+ total T cells (from 70 +/- 16 to 47 +/- 13), OKT4+ helper/inducer T cells (from 44 +/- 9 to 24 +/- 6), and OKT8+ suppressor/cytotoxic T cells (from 27 +/- 7 to 17 +/- 7), but did not significantly affect the OKT4:OKT8 ratio (from 1.64 +/- 0.21 to 1.48 +/- 0.45) or concanavalin A-induced suppressor cell function (from 44 +/- 9% to 47 +/- 13%). Thus, colchicine non-selectively decreased the circulating helper/inducer and suppressor/cytotoxic T cells.

摘要

我们研究了口服秋水仙碱（1 - 2毫克/天）对四名健康志愿者T细胞亚群的影响。秋水仙碱显著（P小于0.01）降低了OKT3 + 总T细胞的平均（±标准差）百分比（从70 ± 16降至47 ± 13）、OKT4 + 辅助/诱导性T细胞（从44 ± 9降至24 ± 6）以及OKT8 + 抑制/细胞毒性T细胞（从27 ± 7降至17 ± 7），但对OKT4:OKT8比值（从1.64 ± 0.21降至1.48 ± 0.45）或伴刀豆球蛋白A诱导的抑制细胞功能（从44 ± 9%降至47 ± 13%）没有显著影响。因此，秋水仙碱非选择性地降低了循环中的辅助/诱导性和抑制/细胞毒性T细胞。

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本文引用的文献

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Correction of a suppressor cell deficiency in four patients with familial Mediterranean fever by in vitro or in vivo colchicine.通过体外或体内使用秋水仙碱纠正四名家族性地中海热患者的抑制细胞缺陷。

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