Nardi N B
Immunogenetics. 1984;20(4):387-95. doi: 10.1007/BF00345613.
The role of suppression in natural and induced tolerance to F antigen was investigated in two sets of experiments. In the first, CBA mice were submitted to pretreatments which decrease suppression and the antibody response to self- or allo-F type was investigated. The second set of experiments involved the transfer of spleen cells from tolerized or from naturally tolerant mice into normal mice which were then primed with allo-F, as well as the co-transfer of tolerant and primed lymphocytes into normal mice, to test whether tolerant lymphocytes present suppressor cells. The results indicate that the immune response against allo-F antigen is normally kept in a low level by a suppressive mechanism, and that F-specific suppressor T cells are absent from tolerant mice.
在两组实验中研究了抑制作用在对F抗原的天然和诱导耐受性中的作用。在第一个实验中，对CBA小鼠进行预处理以降低抑制作用，并研究其对自身或同种F型的抗体反应。第二组实验包括将来自耐受小鼠或天然耐受小鼠的脾细胞转移到正常小鼠中，然后用同种F抗原对其进行免疫，以及将耐受淋巴细胞和经免疫的淋巴细胞共同转移到正常小鼠中，以测试耐受淋巴细胞中是否存在抑制细胞。结果表明，针对同种F抗原的免疫反应通常通过抑制机制保持在低水平，并且耐受小鼠中不存在F特异性抑制性T细胞。
