Rabkin I Kh, Konstantinov B A, Tkachenko V M, Abugov A M, Shchepkin V A
Kardiologiia. 1984 Aug;24(8):67-73.
Seventy-five patients (aged 17-53) with an isolated lesion to the aortal valve have been examined. The study of correlations between clinico-instrumental and angiocardiographic findings has shown that the isotonic overload of the left ventricle as against the isometric one causes more pronounced changes in the contractility of the left ventricular myocardium which are expressed in an increased heart volume, the development of electrocardiographic manifestations of the left ventricular overload, a considerable enhancement in the myocardium weight and in the residual and end diastolic volumes of the left ventricle. The value of the gradient of the systolic pressure in patients with isolated aortal ostium stenosis determines the intensity of myocardial alterations. In patients with aortal valve insufficiency, the value of the pulse pressure is directly correlated with the myocardial state. The contractile function of the left ventricular myocardium in patients with combined cardiac aortal disease is dependent on the predominance of isotonic or isometric overloads of the left ventricle.
对75例（年龄17 - 53岁）单纯主动脉瓣病变患者进行了检查。临床检查与心血管造影结果之间的相关性研究表明，与等长负荷相比，左心室的等张负荷会使左心室心肌收缩力发生更明显的变化，表现为心脏容积增加、左心室负荷的心电图表现出现、心肌重量以及左心室残余舒张末期容积显著增加。单纯主动脉口狭窄患者的收缩压梯度值决定了心肌改变的强度。在主动脉瓣关闭不全患者中，脉压值与心肌状态直接相关。合并心脏主动脉疾病患者的左心室心肌收缩功能取决于左心室等张或等长负荷的优势情况。
