Pourrat J P, Dueymes J M, Conte J J
Presse Med. 1984 Oct 6;13(35):2125-8.
In view of the part played by renal prostaglandins in the mechanisms responsible for pain in renal colic, it was worth trying to find out whether nonsteroidal anti-inflammatory agents, which inhibit prostaglandin synthesis, have an analgesic effect of their own. In a double-blind trial the effects of ketoprofen 100 mg administered intravenously alone or associated with noramidopyrine were investigated in 62 patients divided at random into two equal groups. A rapid analgesic effect was observed with no significant difference between the groups. No severe side-effects were recorded. The double-blind method made it possible to confirm that ketoprofen administered alone relieved pain in 97% of the patients (with complete sedation in 45%) and acted within 5 minutes. Owing to their effectiveness and safety nonsteroidal anti-inflammatory drugs (especially ketoprofen) may be proposed as an alternative to conventional treatments of renal colic. But because of their activity they should not be prescribed until a firm diagnosis has been made. The cause of the colic should also be rapidly determined in order to treat it as well as the pain it produces.
鉴于肾脏前列腺素在肾绞痛疼痛机制中所起的作用，有必要尝试弄清楚抑制前列腺素合成的非甾体抗炎药自身是否具有镇痛作用。在一项双盲试验中，对62例随机分为两组的患者研究了静脉注射100毫克酮洛芬单独使用或与氨基比林联合使用的效果。观察到快速的镇痛效果，两组之间无显著差异。未记录到严重的副作用。双盲法使得能够确认单独使用酮洛芬可使97%的患者疼痛缓解（45%完全镇静），且起效时间在5分钟内。由于其有效性和安全性，非甾体抗炎药（尤其是酮洛芬）可作为肾绞痛传统治疗方法的替代方案。但由于其活性，在做出明确诊断之前不应开此类药物。还应迅速确定绞痛的病因，以便对其以及所产生的疼痛进行治疗。
