el-Baz M A, el-Tayeb Nasser M
Department of Urology, Ain Shams University, Cairo, Egypt.
Int Urol Nephrol. 1995;27(3):245-9. doi: 10.1007/BF02564757.
The non-steroidal anti-inflammatory drug (NSAID) Ketoprofen (Profenid) is used as intravenous monotherapy incorporated in 0.9% normal saline solution (100 mg Ketoprofen ampoule + 200 ml normal saline) in the treatment of renal colic. We present our experience in 65 patients complaining of clinically diagnosed renal colic who were treated by intravenous saline-Ketoprofen. Prospective investigations revaled urinary calculi in 51 patients, oxaluria (crystalluria) in 5, acute colitis in 2, severe myositis in 2, negative investigations in 3 and radiculitis in 2 patients. Positive response was observed in 93.8% of patients as far as pain relief is concerned. Pain relief started within 5-7 minutes after beginning the infusion. Duration of analgesic effect ranged between 4 and 12 hours. Repeating the injection was done for maintenance of analgesia. Side effects included drowsiness in 2 patients, palpitation in 1 patient, epigastric pain in 1, muscular cramp in 1 patient. Ketoprofen, an antiprostaglandin, is a powerful anti-inflammatory and potent analgesic. Intravenous saline-Ketoprofen is a good emergency treatment for acute episodes of renal colic.
非甾体抗炎药酮洛芬（优洛芬）作为静脉单一疗法，加入0.9%的生理盐水溶液（100毫克酮洛芬安瓿+200毫升生理盐水）用于治疗肾绞痛。我们介绍了65例临床诊断为肾绞痛患者接受静脉注射生理盐水-酮洛芬治疗的经验。前瞻性调查发现，51例患者有尿路结石，5例有草酸尿（结晶尿），2例有急性结肠炎，2例有严重肌炎，3例检查结果为阴性，2例有神经根炎。就疼痛缓解而言，93.8%的患者有阳性反应。输液开始后5至7分钟内疼痛开始缓解。镇痛效果持续时间为4至12小时。为维持镇痛效果需重复注射。副作用包括2例嗜睡、1例心悸、1例上腹部疼痛、1例肌肉痉挛。酮洛芬作为一种抗前列腺素药物，是一种强效抗炎和有效的镇痛药。静脉注射生理盐水-酮洛芬是肾绞痛急性发作的一种良好的紧急治疗方法。
