Fein F S, Malhotra A, Miller-Green B, Scheuer J, Sonnenblick E H
Am J Physiol. 1984 Nov;247(5 Pt 2):H817-23. doi: 10.1152/ajpheart.1984.247.5.H817.
Diabetes mellitus causes congestive heart failure in humans, independent of atherosclerosis. The present study extends previous work on the reversibility, with insulin, of the alterations in myocardial function and contractile protein biochemistry observed in diabetic rats. The response of these alterations to different fixed doses of insulin was explored. Diabetic rats were given 0, 0.5, 1, 1.5, 2, or 2.5 U of insulin daily for 6 wk. Papillary muscle function, actomyosin ATPase, and myosin isoenzyme distribution showed progressive normalization with increasing insulin dose as blood glucose concentration returned to normal. Thus insulin therapy in diabetic rats on a normal diet produces continuous improvement in cardiac function and biochemistry as euglycemia is approached. This study also suggests that mild diabetes results in qualitatively identical, although quantitatively less pronounced, myocardial changes compared with those observed in severely diabetic rats.
糖尿病会导致人类充血性心力衰竭，与动脉粥样硬化无关。本研究扩展了之前关于用胰岛素逆转糖尿病大鼠心肌功能和收缩蛋白生物化学改变的可逆性的工作。探讨了这些改变对不同固定剂量胰岛素的反应。给糖尿病大鼠每日注射0、0.5、1、1.5、2或2.5单位胰岛素，持续6周。随着血糖浓度恢复正常，乳头肌功能、肌动球蛋白ATP酶和肌球蛋白同工酶分布显示随着胰岛素剂量增加而逐渐恢复正常。因此，正常饮食的糖尿病大鼠进行胰岛素治疗，随着血糖正常化，心脏功能和生物化学持续改善。这项研究还表明，与重度糖尿病大鼠相比，轻度糖尿病导致的心肌变化在性质上相同，尽管在数量上不那么明显。
