Lange R H, Lange T A, Rao B K
J Bone Joint Surg Am. 1984 Dec;66(9):1454-9.
We reviewed the cases of twenty-four patients with solitary or multiple exostoses to correlate their radiographic, scintigraphic, and histological evaluations. We studied twenty-five excised lesions, two of them exostotic chondrosarcomas, from twenty-two patients. There were two patterns of bone-scan activity and there was a direct correlation between enchondral bone formation and radionuclide uptake in all patients, both skeletally immature and mature. So-called quiescent lesions--those with inactive scans--were those that lacked histological evidence of enchondral bone formation. Those with increased uptake--active exostoses--all demonstrated active formation of enchondral bone. Evidence of active exostotic growth could be demonstrated on bone scans well beyond the time of skeletal maturity. The bone scan did not qualitatively differentiate the benign active exostoses from the two lesions with malignant degeneration. Increased uptake related to enchondral bone formation was a feature of both. An inactive scan, however, seemed to exclude the possibility of malignant degeneration in the exostosis.
我们回顾了24例患有孤立性或多发性外生骨疣患者的病例，以关联其影像学、闪烁扫描和组织学评估结果。我们研究了来自22例患者的25个切除病变，其中2个为外生骨疣性软骨肉瘤。骨扫描活性有两种模式，在所有骨骼未成熟和成熟的患者中，软骨内成骨与放射性核素摄取之间存在直接关联。所谓的静止性病变——扫描无活性的病变——是那些缺乏软骨内成骨组织学证据的病变。摄取增加的病变——活跃的外生骨疣——均显示有软骨内成骨的活跃形成。在骨骼成熟后的很长时间里，骨扫描都能显示活跃的外生骨疣生长迹象。骨扫描无法从定性上区分良性活跃外生骨疣与两个发生恶性变的病变。与软骨内成骨相关的摄取增加是两者的特征。然而，无活性扫描似乎排除了外生骨疣发生恶性变的可能性。
