Andreu J, Barsotti J, Laudat P, Audurier A
Rev Chir Orthop Reparatrice Appar Mot. 1984;70(6):423-8.
Eleven hundred and sixty eight traumatic cases have been operated on under constant conditions in a conventional operating room with filtered air and positive pressure using absolute filters of 99.999 efficiency. Two hundred and five were submitted to post-operative prophylactic administration of Cephalosporin (Cefazolin) for 2 days. The overall results showed 0.6 p. 100 of infection but 4 cases of severe sepsis were seen in the group of patients who had received prophylactic antibiotics. The authors have compared these results with those obtained during the previous period when the operating room was less modern. They conclude that this factor is of paramount importance. On the other hand, they have observed 2.1 p. 100 of contaminated drains without subsequent infection. They are concerned at the increase of gram-negative organisms resistant to Cefazolin (60 p. 100) and of Staphylococci resistant to Methicillin (30 p. 100). They conclude that the peroperative flash technique of the administration of Penicillin M is worthwhile.
1168例创伤病例在配备过滤空气和正压的传统手术室中，使用效率为99.999%的绝对过滤器，在恒定条件下进行了手术。205例患者术后预防性使用头孢菌素（头孢唑林）2天。总体结果显示感染率为0.6%，但在接受预防性抗生素治疗的患者组中出现了4例严重脓毒症病例。作者将这些结果与手术室不太现代化的上一时期所获得的结果进行了比较。他们得出结论，这个因素至关重要。另一方面，他们观察到2.1%的引流管被污染，但随后并未发生感染。他们对耐头孢唑林的革兰氏阴性菌（60%）和耐甲氧西林的葡萄球菌（30%）的增加感到担忧。他们得出结论，术中快速注射青霉素M的技术是值得的。
