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[免疫记忆形成抑制的机制]

[Mechanism of the suppression of the formation of immunologic memory].

作者信息

Aleĭnik D Ia, Pisarev V M, Pevnitskiĭ L A

出版信息

Biull Eksp Biol Med. 1984 Nov;98(11):584-6.

PMID:6239663
Abstract

An extract from splenocytes of mice immunized with sheep red blood cells contains suppressor factor (SF) that specifically inhibits the primary immune response. The system of adoptive transfer was studied for the action of the SF on the formation of immunologic memory for sheep and rat blood cells. It was established that the SF carrying a receptor for specific antigen causes nonspecific suppression of the generation of immunologic memory cells. Within the system in question radioresistant T helper cells act as suppression targets. It is suggested that the final effect of the SF lies in the inhibition of the release of transmitters promoting differentiation or proliferation of T memory cells.

摘要

用绵羊红细胞免疫的小鼠脾细胞提取物中含有特异性抑制初次免疫反应的抑制因子(SF)。采用过继转移系统研究了SF对绵羊和大鼠血细胞免疫记忆形成的作用。已确定携带特异性抗原受体的SF会对免疫记忆细胞的产生产生非特异性抑制作用。在该系统中,辐射抗性T辅助细胞是抑制靶点。有人认为,SF的最终作用在于抑制促进T记忆细胞分化或增殖的递质释放。

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