4-氢过氧环磷酰胺对刀豆蛋白A诱导的人抑制性T细胞的体外作用。
In vitro effects of 4-hydroperoxycyclophosphamide on concanavalin A-induced human suppressor T cells.
作者信息
Klajman A, Drucker I, Manor Y, Ben-Efraim S
出版信息
Cancer Immunol Immunother. 1984;18(2):113-7. doi: 10.1007/BF00205744.
Abstract
Treatment in vitro of human peripheral blood lymphocytes (PBL) with ConA induced the generation of suppressor cells which inhibited T cell blastogenic response to ConA and of allogeneic response in the mixed lymphocyte reaction (MLR). Treatment of PBL with 4-hydroperoxycyclophosphamide (4-HPCy) before incubation with ConA markedly decreased the generation of suppressor cells by ConA. The effect of 4-HPCy on generation of suppressor cells was more pronounced in the test of ConA stimulation than in the MLR. Treatment with 4-HPCy had no effect on suppressor cells already induced as shown by incubation of PBL with 4-HPCy after incubation with ConA.
摘要
用刀豆蛋白A（ConA）对人外周血淋巴细胞（PBL）进行体外处理，可诱导抑制细胞的产生，这些抑制细胞会抑制T细胞对ConA的增殖反应以及混合淋巴细胞反应（MLR）中的同种异体反应。在与ConA孵育前先用4-氢过氧环磷酰胺（4-HPCy）处理PBL，可显著减少ConA诱导的抑制细胞的产生。在ConA刺激试验中，4-HPCy对抑制细胞产生的影响比在MLR中更明显。如在与ConA孵育后再用4-HPCy孵育PBL所示，4-HPCy处理对已诱导产生的抑制细胞没有影响。
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本文引用的文献
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