人妊娠血清抑制白细胞介素-2的产生。
Human pregnancy serum inhibits interleukin-2 production.
作者信息
Nicholas N S, Panayi G S, Nouri A M
出版信息
Clin Exp Immunol. 1984 Dec;58(3):587-95.
Cell-mediated immunity may be depressed during pregnancy. We used the two way mixed lymphocyte reaction as an in vitro model of cell mediated immunity and studied the effect of pregnancy sera on this system by the amount of tritiated thymidine taken up by activated lymphocytes. We found that: (1) pregnancy sera contain a factor inhibiting the mixed lymphocyte reaction; (2) the inhibition of the mixed lymphocyte reaction induced by sera could be reversed by the addition of the supernatant from allogeneic mixed lymphocyte reaction; (3) pure interleukin-1 could not reverse the inhibitory effect and (4) recombinant interleukin-2 (IL-2) completely reversed the inhibitory effect of pregnancy sera on the mixed lymphocyte reaction. We conclude that a factor (or factors) present in serum from pregnant women is capable of inhibiting the generation of IL-2 during lymphocyte activation.
孕期细胞介导的免疫功能可能会受到抑制。我们采用双向混合淋巴细胞反应作为细胞介导免疫的体外模型，并通过活化淋巴细胞摄取氚标记胸腺嘧啶核苷的量来研究妊娠血清对该系统的影响。我们发现：（1）妊娠血清中含有一种抑制混合淋巴细胞反应的因子；（2）血清诱导的混合淋巴细胞反应抑制作用可通过加入同种异体混合淋巴细胞反应的上清液而逆转；（3）纯白细胞介素-1不能逆转这种抑制作用；（4）重组白细胞介素-2（IL-2）可完全逆转妊娠血清对混合淋巴细胞反应的抑制作用。我们得出结论，孕妇血清中存在的一种（或多种）因子能够在淋巴细胞活化过程中抑制IL-2的产生。
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