新生儿及其母亲的单核细胞产生白细胞介素-1。
Production of interleukin-1 by mononuclear cells of newborns and their mothers.
作者信息
Bessler H, Sirota L, Dulitzky F, Djaldetti M
机构信息
Department of Medicine B, Hasharon Hospital, Petah-Tiqva, Israel.
出版信息
Clin Exp Immunol. 1987 Jun;68(3):655-61.
Abstract
The ability of peripheral blood mononuclear cells derived from newborn infants, their mothers and healthy adults to produce interleukin 1 (IL-1) was examined. It was found that newborn and maternal mononuclear cells have a normal capacity to produce IL-1. In addition, a lower stimulatory activity of IL-1 production was found in maternal serum, suggesting another mechanism for the suppression of the maternal immune system during pregnancy. Furthermore, evidence is presented on the existence of sex-related blocking factors in the maternal serum which affect IL-1 production.
摘要
研究了来自新生儿、其母亲和健康成年人的外周血单个核细胞产生白细胞介素1（IL-1）的能力。发现新生儿和母亲的单个核细胞具有产生IL-1的正常能力。此外，在母亲血清中发现IL-1产生的刺激活性较低，这表明孕期母亲免疫系统受到抑制的另一种机制。此外，还提供了证据证明母亲血清中存在影响IL-1产生的性别相关阻断因子。
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